成瘾剂量（2021）

Dopesick S01E02

Part 9 Nov. 5, 2021, 11:59 a.m.

去全国各地参加这样的活动
to go to events like this around the country.
每次演讲可以拿到500到3000美元
They get $500 to $3,000 for a speech.
那些演讲者是花钱请的
‐ Those speakers get paid?
是呀不是秘密了
‐ Oh, yeah. It's not a secret.
你该考虑一下
You should think about it.
你在台上表现很棒
‐ You were great up there.
那人太棒了
That guy's amazing.
是啊
‐ Mm. Yeah.
他他真的很特别
He's, uh‐‐he's really special.
你♥爸♥爸的事深表遗憾
‐ And I'm sorry about your dad.
他现在好了吗
Is he okay now?
这个我
‐ Yeah, I, uh...
是我编的
I made that up.
我我爸从来没得过癌症
My, uh‐‐my dad never had cancer.
这是我第一次
This is the first time
想上了你
that I've ever wanted to fuck you.
你你想做点什么吗
‐ You, uh‐‐you want to do something about that?
威廉不用了
‐ Oh, oh, William, I don't think so.
第一次
But just because this is the first time
并不意味着就是最后一次
doesn't mean that it's the last.
一个月一次你可以同时享受快乐周末
‐ Once a month, you could have a fun weekend for yourself
还能看见我灿烂的笑容
and you'd get to see my big smile
前提是你不介意的话
if it wouldn't bother you too much.
我不觉得有人会介意
Oh, I don't think seeing your smile
看到你的笑容
would bother anyone.
你不是说有用吗
‐ I thought you said it was working.
之前有用
BETSY: It was.
去去就回
I'll be right back.
多起案例表明
‐ There are many cases where a higher dose
高剂量药物会导致药效失效速度加快
loses its effectiveness fairly quickly
因为患者产生了耐受性
because the patient develops a tolerance.
这会让使用者很快就再次
PROFESSOR: This makes the user increase their dose again
增加剂量
at a fast rate.
那样危险吗
‐ And is that dangerous?
当然
‐ Absolutely.
这就是为什么奥施康定的过量服用现象
It's one of the reasons why overdose rates
要高很多的原因之一
are so much higher on OxyContin.
这些是新的数据
MICHAEL: These are the new numbers,
你会发现同最初的数据有着
and you'll see a significant difference
显著不同
from the initial rollout figures.
好多了
RICHARD: Better.
干得相当不错里奇
‐ Really great job, Richie.
真是太好了
‐ That's really great.
是的销♥售♥情况有了
‐ Yes, yes, there's been a definite improvement
明显改善
in the sales figures.
我们还发现参加过周末研讨会的
We also found doctors who attended the weekend seminars
医生开的处方是没参加过研讨会的
have been writing twice as many prescriptions
医生的两倍
as doctors who don't.
那我们应该多举办几个周末研讨会
‐ Then we should throw more weekend seminars.
但是更重要的是剂量翻倍
‐ But, um, more significantly, doubling the dose
不仅解决了突破性疼痛的问题
not only solved the breakthrough pain issue,
还增加了我们的净收入
it increased our bottom line,
因为生产20毫克或40毫克的成本
since manufacturing a 20 milligram or 40 milligram
几乎等同于生产10毫克的成本
is almost the same cost as a 10 milligram.
进账速度
This is bringing in revenue
比预计的要快的多
at a much faster rate than projected.
有种情况我一直很担心
‐ There's a scenario I've been concerned about.
是什么呢我亲爱的表妹
‐ And what is that, my dear cousin?
如果有人患有突破性疼痛
‐ Well, what happens if someone has breakthrough pain
且已经服用了40毫克剂量那会发生什么
and they're already at 40 milligrams?
上季度的销♥售♥报告非常出色
‐ The sales reports from last quarter were terrific,
以至于我很高兴地宣布
so much so that I am pleased to announce
我们将推出一款全新产品
that we will be launching a brand‐new product.
女士们先生们是时候再加倍剂量了
Ladies and gentlemen, it is time to double the dose again
隆重向各位介绍 80毫克装药片
as I present to you the 80‐milligram pill.
她是我的宝贝
MAZZY STAR:? She's my baby ?
她属于我
? She belongs to me ?
但昨天她独自走回家
? But yesterday she walked home all alone ?
别人都看着我的宝贝
? Everybody else looks at my baby ?
然后他们向我走来
? Then they wander over to me ?
但宝贝今天不开心
? But baby's feelin' bad today ?
她说她想离开
? She said she's thinkin' of goin' away ?
我在哭泣
? And I'm cryin' ?
身体在飞翔
? And my body's flyin' ?
但我记得你
? But I remember you ?
她是我的宝贝
? She's my baby ?
是不是很了不起
? Ain't that something? ?
但我知道
? But I know ?
她属于她属于你
? She belong‐‐ she belongs to you ?
突发性疼痛
奥施康定
30毫克/天
急诊室药物过量病例急剧上升
处方止疼药是罪魁祸首
哈伦县
疼痛门诊
头痛和脊柱保健中心
肯塔基州
哈伦县
普渡
美国疼痛基金会
全国疼痛治疗基金会
美国慢性疼痛协会
拉塞尔·波特诺伊医生
斯隆凯特林中心疼痛和姑息治疗服务的
联合负责人
决不会导致成瘾
不当使用长效阿片类药物（以4小时服药间隔时间为基准）
阿片类药物血浓度
（峰值）镇静产生快♥感♥
疼痛缓解
疼痛复发
恰当使用长效阿片类药物（以12小时服药间隔时间为基准）
阿片类药物血浓度
镇静且/或极小的快♥感♥
疼痛缓解
疼痛复发频率减少
恰当使用长效阿片类药物（以12小时服药间隔时间为基准）
镇静产生快♥感♥
镇静产生快♥感♥
疼痛缓解
疼痛复发
阿片类药物血浓度
伊卡洛斯，希腊神话中代达罗斯的儿子，因飞得太高双翼上的蜡遭太阳融化跌落水中
詹姆斯·科米（James Comey），美国政♥府♥官员，共和党人。
曾在2003年至2006年期间担任美国司法部副部长。曾任美国联邦调查局(FBI)局长
阿片类镇痛药主要包括可待因、双氢可待因、氢吗♥啡♥酮、羟考酮、美♥沙♥酮♥、吗♥啡♥、芬太尼和哌替啶(度冷丁)等。
克♥林♥顿♥总统同父异母的弟弟
奥斯康定等止疼药的推广者
罗纳德·里根第40任美国总统
Pharm(制药）与Farm(农场)同音
世界卫生组织对姑息治疗的定义是"姑息治疗医学是对那些对治愈性治疗不反应的病人完全的主动的治疗和护理。控制疼痛及患者有关症状，并对心理、社会和精神问题予以重视