他生动地讲述自己的
He talks very vividly
增重和减重
about his weight gains and weight losses.
你说过想搞一个惊喜的
You wanted it to be a surprise.
他向莫妮卡求婚
He has a very vivid description
那段剧情
of the scenes
他描述得很生动
when he's proposing to Monica.
我以为
I thought...
等一下 我可以的
Wait, I can do this!
当他们下一季回归的时候
When they come back the next season,
他体型变化得非常明显
there's such a marked difference in his weight.
莫妮卡和我订婚了
Monica and I are engaged.
我的天呐
Oh, my God!
来吧
Come on.
恭喜
Congratulations.
詹妮弗·安妮斯顿后来透露了剧组如何努力帮他克服成瘾问题
马修不知道的是什么呢
What doesn't Matthew know?
就是他没问题
That he's all right.
我们不知道
We didn't know.
你知道吗 我们没有准备
We, you know, we weren't equipped,
我们不知道怎么解决
we weren't-- To deal with it.
你懂吗 大家没有处理过这种情况
You know? Nobody had ever dealt with that.
我试过向他伸出援手
I tried to reach out a little bit
我想让他知道我在他身边
and let him know I was there for him
因为我生活里也有一些人
because I have had other people in my life
经历过酗酒或毒瘾
who've had trouble with alcohol or drugs,
我想让他知道 他随时可以找我聊聊
and I'm here to talk if you would like to.
他的生活完全被成瘾问题笼罩了
His life was overtaken by addictions
他写到在每一个阶段里
that in each phase that he writes about,
他会找到一个新办法
he finds a new way
尝试 控制 然后失败
to try and handle and never can.
他说他大概花了九百万美元
He talks about spending more than $9 million,
至少12次试图戒毒
going to detox more than at least 12 times.
我半辈子都在治疗中心或戒毒所
I have lived half my life in one form or another
过着这样或那样的日子
off a treatment center or a sober living house.
你24岁的时候这样没什么
Which is fine when you're 24 years old,
但42岁的时候就不太能接受了
less fine when you're 42 years old.
现在我49岁
Now I was 49,
我还在尝试摆脱它
still struggling to get this monkey off my back.
他要不就是说 要参加一个新的戒毒项目
He talks about going to yet another detox program,
要不就是说 去一个新地方戒毒
yet another place, this time in Switzerland,
在瑞士 他第一次接触氯♥胺♥酮♥
and this was the first time he was introduced to ketamine
你可以从他的文字里看出
and you can tell by the way he writes
那一次给他留下了深刻印象
that it made an impression on him.
我也在每天注射氯♥胺♥酮♥
I was also doing ketamine infusions every day.
氯♥胺♥酮♥是八十年代非常流行的街头毒品
Ketamine was a very popular street drug in the '80's.
现在有一种它的人工合成品
There is a synthetic form of it now
用于两种情况
and it's used for two reasons:
减轻疼痛 和治疗抑郁
to ease pain, and help with depression.
它就像为我量身定做的
It has my name written all over it.
甚至不如直接叫它马蒂
They might as well have called it Matty.
氯♥胺♥酮♥让人感觉如释重负
Ketamine felt like a giant exhale.
就像被一把巨大的快乐铲子当头一击
Like being hit in the head with a giant happy shovel.
圣迭戈 加利福尼亚州
马修·派瑞描述
Matthew Perry described
他第一次被注射氯♥胺♥酮♥
his first treatment with ketamine
大卫·伊费尔 医学博士
Kadima神经精神病治疗机构
感觉像被一把巨大的快乐铲子当头一击
as being hit over the head with a happy shovel,
我对此并不奇怪
it doesn't surprise me at all.
这个经历对于马修来说
What Matthew Perry experienced
是对抑郁症的摆脱
was this lifting of this depression.
氯♥胺♥酮♥的特点在于
And what's profound about ketamine
它几乎可以瞬间起效
is it does it almost instantaneously.
通常来这里的患者
Typically, the patients that come here
都尝试过传统的治疗手段
are patients that have tried conventional treatments
来对抗抑郁症 焦虑症 创伤后应激障碍
for things like depression, anxiety, PTSD,
他们发现
and they just found that
那些方法根本没有效果
they were really not making any progress.
所以他们来这的时候说 我需要点不一样的
So they come in saying, "I need something different."
你好 安妮 -你好 费菲尔医生
Hi, Annie. - Hi, Dr. Feifel.
很高兴见到你 -见到你我也很高兴
Great to see you. - It's good to see you too.
我记得距离你上次来治疗
So it's been about three weeks, I think,
已经过了三周了 对吧
since your last treatment, right?
是的
Yup.
如果你愿意 氯♥胺♥酮♥其实是一个很古老的药物
Ketamine is actually a very old drug, if you will.
我是说 它是在上世纪六十年代
I mean, it's a drug that was developed
作为麻醉剂被开♥发♥的药物
in the 1960s as an anesthetic.
在较低剂量下
At lower doses,
这款药治疗精神疾病的效果
this drug seems to have remarkable properties
似乎很显著
for treating mental illness.
这个背后的逻辑是
And the idea behind that
它能驱使大脑和心理状态
is it kind of kick starts the brain changes
开始发生改变
and the psychological changes
从而产生疗效
that can have that therapeutic effect.
在医学观察的环境下治疗患者
Treating patients in a medically observed environment
至关重要
is critical,
因为氯♥胺♥酮♥会导致
because ketamine can result
患者失去意识
in a person losing consciousness.
我们会持续监测
We're always continuously monitoring
患者的血压
patients' blood pressure,
心率和氧合状态
their heart rate, and their oxygenation status.
一小时后
你好 安妮 -你好
Hi, Annie... - Hello.
你感觉如何
How are you feeling?
我觉得不错 挺好的
I'm doing good. Good.
我真的希望能更普及这种治疗
I really hope that this becomes a more accessible treatment.
因为我知道很多人
Because I know so many people
会陷入一种困境 觉得自己必须依赖
who are stuck feeling like they have to depend
选择性血清素再摄取抑制剂 或者药物什么的但又总是没什么效果
on SSRIs or pills and stuff and they don't always work.
我们大多数的患者
The majority of our patients
记录了治疗后几天到几周的状态
report for the days and weeks afterwards,
他们觉得自己情绪更正常了
they just feel like they have more normal emotions,
不再受抑郁 焦虑 创伤后应激障碍的影响
they're free of the depression, the anxiety, the PTSD.
它改善病情的速度
The speed at which it can improve things
是前所未有的
is unprecedented.
洛杉矶 加利福尼亚州
根据验尸结果
According to the autopsy report,
他血液里有大量的氯♥胺♥酮♥
he had high levels of ketamine in his blood.
根据报道 派瑞正在接受
With Perry reported to be receiving
氯♥胺♥酮♥输注治疗抑郁症和焦虑症
ketamine infusion therapy for depression and anxiety.
但是 调查发现
However, an investigation concluded
这些氯♥胺♥酮♥并不来自输液治疗
the ketamine did not come from the infusion therapy,
因为他最后一次治疗
as his last treatment
是在死前一周半做的
was a week and a half before his death,
而药物在体内几个小时就代谢掉了
and the drug clears the system in a few hours.
氯♥胺♥酮♥是一种管控物质
Ketamine is a controlled substance.
它是一种有合法用途的物质
It is a substance that can have legitimate purposes,
但必须由受过训练的
but it has to be administered
专业人员管理
by trained professionals.
不幸的是 它也是一种被滥用的药物
Unfortunately, it is a drug that is also abused.
派瑞先生又重新染上了药瘾
Mr. Perry fell back into addiction.
他开始寻找
And he began searching
氯♥胺♥酮♥的其他来源
for additional sources of ketamine.
如果你是个瘾君子
If you're an addict,
任何可能被滥用的东西都会唤醒那头野兽
anything that can be abused can sort of wake that beast up.
好莱坞到处是诱惑的推手
Hollywood is full of enablers,
而且我觉得 不只好莱坞如此
and I don't think that's unique to Hollywood.
在任何一个
I think any industry
暴利产业里
where there's a lot of money to be made,
你总能找到推手
you're always gonna find enablers.
这里面包含极多的犯罪行为
There's a whole plethora of criminal activity.
他们给马修·派瑞提供大量氯♥胺♥酮♥
They supplied Matthew Perry with large amounts of ketamine,
作为交换他们会收一笔巨款
in exchange for large sums of money.
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